# Startups Crafting Breakthroughs That Improve Living — and Dying
Innovative startups are revolutionizing how we live longer, healthier lives and face the end with dignity, harnessing AI, wearables, and sustainable tech to tackle aging, chronic care, and environmental health challenges. In 2025, these companies are not just extending lifespans but enhancing quality of life from cradle to grave, addressing everything from forest conservation to senior empathy platforms.[1][3][5]
AI-Powered Health and Longevity Innovations Transforming Daily Living
Startups are leveraging AI-driven tools to monitor health in real-time, personalize care, and promote preventive wellness, making healthy living more accessible. For instance, Liv Longevity Labs offers TruAge, an at-home saliva test analyzing DNA methylation to determine biological age, providing accurate health outcome predictions over chronological age.[3] Similarly, Clarence Health deploys an AI platform for seniors, delivering medication reminders, social engagement to combat loneliness, and proactive insights integrated with care teams.[3]
Ro, a telehealth leader, streamlines consultations for conditions like hair loss, erectile dysfunction, and smoking cessation, with door-delivered medications and unlimited follow-ups.[2] BASIS Health supports longevity through subscription meal deliveries using organic ingredients and low-temperature cooking to minimize harmful compounds.[3] These solutions empower users with data-driven habits, from Tolion Health's brain health app to Longevity Copilot's lifestyle adoption tools.[3]
Sustainable Tech and Climate Solutions for a Healthier Planet and Lifestyle
Climate-health intersections are gaining traction, with startups improving living conditions through eco-friendly tech. Pachama uses AI and satellite imagery for real-time forest monitoring, verifying carbon credits to combat fraud in offset markets and support verifiable reforestation.[1] Uplight optimizes energy use via AI platforms for demand management and virtual power plants, enhancing grid reliability and decarbonization.[1]
Ceres AI analyzes aerial imagery for precise water and crop management, boosting farm efficiency and reducing environmental impact.[1] Monumental employs autonomous vehicles for affordable housing construction, cutting labor costs, errors, and timelines to make quality homes accessible.[1] These innovations align health with sustainability, addressing climate-related challenges like air quality and heat stress.[4]
End-of-Life and Senior Care Breakthroughs Easing the Dying Process
Startups are humanizing aging and end-of-life care with empathetic tech, extending quality years. juli personalizes chronic condition management via AI, fostering long-term health improvements for healthy aging.[5] TELL detects neurological conditions through AI voice biomarkers for early intervention and better diagnostics.[5]
Waterlily simplifies long-term care planning with an AI platform comparing policies, preparing families for extended lifespans.[5] Zencey offers affordable telemedicine subscriptions from $4/month, expanding access in underserved regions.[5] Cadence aids chronic patients with remote monitoring and telehealth, while Clarence Health combats senior isolation through daily AI interactions.[3][9] Anti-aging biotech like EvaGene's home DNA testing and For Life Longevity's nutraceuticals further slow aging processes.[3][8]
Investor Insights and Future Trends in Healthtech for 2025
Investors spotlight inclusive, preventive healthtech, with miniaturized wearables and AI companions for older adults enabling at-home monitoring.[4] Accelerators like Tampa Bay Wave's HealthTech|X cohort feature 16 startups in virtual care and diagnostics, such as Endless Health.[6] Trends include real-world data platforms like Tempus and consumer genomics from 23andMe.[7]
Diversity-focused telehealth for underserved communities and climate-health convergence signal robust growth, with longevity economy innovators like Givers standardizing caregiving.[4][5] These predictions underscore a shift toward scalable, equitable solutions.[2][9]
Frequently Asked Questions
What are some top AI startups improving health and longevity in 2025?
Key players include **Liv Longevity Labs** with *TruAge* biological age testing, **Clarence Health** for senior engagement, and **Ro** for telehealth services, all using AI for personalized care.[2][3]
How are startups addressing climate and sustainability to enhance living?
**Pachama** verifies carbon offsets via satellite AI, **Uplight** manages energy flexibility, and **Ceres AI** optimizes farming resources, reducing environmental footprints.[1]
Which innovations help with end-of-life and senior care?
**Waterlily** aids care planning, **TELL** detects neurodegeneration via voice AI, and **juli** manages chronic conditions, improving quality of life in aging.[3][5]
What role do wearables and biomarkers play in these startups?
Wearables from **Liv Longevity Labs** and biomarker tools like **Kyma Health** track aging at cellular levels for proactive health management.[3]
Are there startups focused on affordable housing or food for better living?
**Monumental** uses autonomous tech for cheaper housing, while **BASIS Health** delivers longevity-focused organic meals.[1][3]
What trends predict the future of healthtech startups in 2025?
Investors highlight preventive AI, inclusive telehealth, and climate-health tech, with accelerators nurturing diagnostics and virtual care innovations.[4][6]
🔄 Updated: 12/18/2025, 9:31:07 PM
U.S. regulators have stepped up scrutiny of startups building technologies that *improve living — and dying*, with multiple federal actions this year aimed at tightening privacy, safety and prescribing rules for health AI and end‑of‑life tools. The Department of Health and Human Services has advanced proposed updates to the HIPAA Security Rule requiring stronger risk management and data protections for PHI[1], the FDA and lawmakers are debating the Healthy Technology Act to permit — with new oversight — AI/ML systems to act as prescribers if authorized by FDA and states[5], and CMS/ONC rules accelerating interoperability and prior‑authorization modernization will force startups to support new APIs
🔄 Updated: 12/18/2025, 9:41:01 PM
Startups are deploying generative AI, advanced sensors, and regenerative biotech to extend life and ease dying—ambient-scribe AI alone generated about $600 million in 2025 and is concentrated among startups capturing roughly 70% of the new market (Abridge ~30%, Ambience ~13%) while incumbents like Nuance still hold ~33%[6]. Venture-backed cohorts (e.g., MedTech Innovator’s 64-company 2025 cohort) and accelerators are moving 400+ products toward market and competitive non-dilutive pools (e.g., $800,000 prize funds), signaling rapid translation from prototype to regulated clinical use with
🔄 Updated: 12/18/2025, 9:51:01 PM
**NEWS UPDATE: Startups Crafting Breakthroughs That Improve Living — and Dying**
Sahir Ali, solo general partner at Modi Ventures, hails Rubedo Life Sciences as a "standout example" of longevity therapeutics for its AI-driven Alembic platform, which uses single-cell RNA sequencing to develop senolytic drugs targeting senescent cells across age-related diseases[2][5]. BioAge Labs' drug discovery engine, powered by AI models on human aging cohorts, uncovers novel metabolic pathways, bolstered by a key Novartis partnership to enhance health outcomes in aging[3]. Meanwhile, Life Biosciences' Partial Epigenetic Reprogramming (PER) platform reverses aging hallmarks, with ER-10
🔄 Updated: 12/18/2025, 10:01:08 PM
Experts say startups blending **cellular reprogramming, senolytics, and AI-driven biomarker platforms** are shifting the industry from longevity hype to clinically actionable interventions, with firms like Altos Labs, BioAge and Rubedo drawing tens to hundreds of millions in funding and advancing programs toward human trials[2][5]. Industry analysts note the field’s pivot to measurable outcomes — e.g., Retro Biosciences’ reported $180M raise and claims of up to 50x improvements in stem-cell protein engineering, and Life Biosciences’ plan to start first-in-human partial epigenetic reprogramming trials in 2026 — and warn regulators and
🔄 Updated: 12/18/2025, 10:11:00 PM
**LIVE NEWS UPDATE** — The World Economic Forum's 2025 Technology Pioneers cohort, featuring **100 startups from 28 countries**, is driving global breakthroughs in smart robotics, spatial AI, and quantum computing to tackle pressing challenges like cybersecurity and space-based data centers, with firms like BforeAI blocking malicious campaigns via predictive AI and Starcloud enabling gigawatt-scale solar-powered computing in orbit[1]. Internationally, ecosystems are surging—**Bengaluru jumped 7 spots to #14** in Startup Genome's rankings while **Hong Kong leaped into the top 27**, fueled by AI-native transitions and $750 million+ raised by 109 climate tech applicants from 13 nations, as Trellis highlight
🔄 Updated: 12/18/2025, 10:21:01 PM
**NEWS UPDATE: Healthcare AI Startups Surge with Massive Funding Amid Investor Frenzy**
Venture capital in health tech startups hit $3.9 billion in Q3 2025, surpassing 2024's full-year total, fueled by AI breakthroughs like Ambience Healthcare's $243 million Series C and OpenEvidence's $210 million Series B, signaling strong market confidence in tools improving clinical workflows and end-of-life care efficiency[1][5]. Ambient AI scribes alone generated $600 million in 2025 revenue, up 2.4x year-over-year, crowning unicorns Abridge (30% market share) and Ambience (13%), though incumbent Nuance holds 33%[3]. Public market reaction
🔄 Updated: 12/18/2025, 10:31:01 PM
Startups focused on both extending healthy life and improving end-of-life care reported fresh breakthroughs this week: Seattle’s Circulate Health announced a $12 million seed round to scale therapeutic plasma exchange clinics aimed at reducing age-related biomarkers, led by Khosla Ventures[7]. Meanwhile, Clarence Health unveiled a pilot that cut senior missed-medication events by 32% using empathetic AI engagement and care-team integration, and longevity drug developers such as Junevity and Shift Bioscience disclosed new rounds and platform advances (Junevity raised $16M seed; Shift has $18M total) to accelerate cell-reset and AI-guided rejuvenation therapies[1][3
🔄 Updated: 12/18/2025, 10:41:00 PM
**NEWS UPDATE: Startups Crafting Breakthroughs That Improve Living — and Dying**
Fresh from stealth, Seattle's Circulate Health launched therapeutic plasma exchange services in July 2025, raising $12 million in seed funding led by Khosla Ventures to extend healthy lifespans through blood purification[9]. Meanwhile, 2024-founded Clarence Health debuted its AI platform in Columbus, Ohio, boosting senior longevity with daily empathetic interactions, medication reminders, and care coordination that combats loneliness and integrates family teams[1]. Tolion Health, also launched in 2024 from Prague, rolled out an ML-powered brain app assessing dementia risk for at-risk users, redefining neurodegenerative prevention[1].
🔄 Updated: 12/18/2025, 10:51:00 PM
**NEWS UPDATE:** Healthtech startups are pioneering AI-driven breakthroughs like Tempus's FDA-approved xT CDx test and upgraded AI assistant Tempus One, enabling precision cancer diagnostics via advanced data analysis for targeted therapies and superior patient outcomes[3]. Akasa's AI automates hospital revenue cycle management, securing $250 million in funding and clients like Cleveland Clinic by interpreting medical records for accurate reimbursements, while Infinitus deploys AI agents for 24/7 pharma patient queries on medications, slashing administrative bottlenecks[2]. These innovations signal a shift toward efficient dying processes through early detection and personalized end-of-life care, with 85% of global healthcare leaders investing in generative AI to boost clinician productivity and remote monitoring
🔄 Updated: 12/18/2025, 11:01:01 PM
Startups are forcing a sharp reordering of the healthcare competitive landscape as venture dollars and market share flow to AI-native challengers: in 2025 startups captured roughly **85%** of generative-AI healthcare spending and ambient scribe revenues grew to about **$600 million** (+2.4x YoY), with Abridge and Ambience taking ~30% and ~13% of that segment respectively while Nuance/DAX still holds ~33%[5]. Investors are moving toward later-stage, sustainability-focused bets—deal volume has dropped since 2021, funding concentrated in non-clinical and clinical workflow and data infrastructure (which together drew
🔄 Updated: 12/18/2025, 11:11:01 PM
Venture dynamics in health and end‑of‑life startups have shifted from volume to precision: deal volume has fallen since 2021 even as AI-enabled health startups captured 85% of generative‑AI healthcare spending in 2025, forcing companies to prove traction or lose investor interest[3][5]. As a result, late‑stage rounds and IPOs are rising while incumbents like Epic and Nuance re‑tool to defend share—ambient scribe startups Abridge and Ambience now claim roughly 30% and 13% of that $600M category (Nuance’s DAX Copilot still near 33%), prompting rapid product expansion
🔄 Updated: 12/18/2025, 11:21:01 PM
Startups are deploying AI-driven diagnostics, remote monitoring, and regenerative therapies that measurably shift patient trajectories — for example, ambient-scribe vendors generated roughly $600 million in 2025 (+2.4x YoY), with Abridge holding ~30% market share and Ambience ~13%, demonstrating rapid clinical workflow automation adoption[7]. Technical implications include widespread model integration across EHRs and medical devices (boosting clinician throughput and enabling real‑time prior authorization) but also increased dependence on validated model performance, data‑shift monitoring, and regulatory-grade explainability to avoid diagnostic drift and billing errors[3][7][5].
🔄 Updated: 12/18/2025, 11:31:00 PM
**LONDON (NEWS UPDATE)** – UK-based Kyma Health, founded in 2024, launched an AI-powered app enabling at-home blood tests that analyze biomarkers for metabolism, nutrition, and inflammation to personalize women's healthcare and boost longevity[1]. Meanwhile, Genflow Biosciences secured €4 million ($4.3 million) from Belgium's Wallonia region to advance its gene therapy GF-1002, targeting age-related diseases like MASH in humans and dogs[2]. Investors are buzzing as Insilico Medicine raised $110 million for AI-driven drugs against aging-related conditions, signaling a shift toward practical longevity breakthroughs[6].
🔄 Updated: 12/18/2025, 11:41:01 PM
**Healthcare AI startups like Abridge and Ambience Healthcare have fueled a venture funding surge, raising $550 million and $243 million respectively in 2025 mega-rounds, crowning them unicorns amid $3.9 billion in Q3 health tech investments—surpassing 2024 totals.** Public digital health IPOs from Hinge Health (May, NYSE) and Omada Health (June, Nasdaq) reflect market maturation, while established healthcare stocks shine with year-to-date gains led by **IDXX at 74.86%**, **CAH at 67.70%**, and **HCA at 52.50%** as of December 2025.[5][1][2][
🔄 Updated: 12/18/2025, 11:51:00 PM
**LIVE NEWS UPDATE**
The World Economic Forum's 2025 Technology Pioneers cohort features **100 startups from 28 countries**, deploying AI, advanced robotics, and quantum computing to tackle global challenges like sustainable data centers and affordable space access, with companies such as Starcloud enabling gigawatt-scale solar-powered computing in orbit.[1] Internationally, ecosystems are surging—Asia's Bengaluru jumped seven spots to #14 and Hong Kong debuted at #27 in the Global Startup Ecosystem Report 2025—while Europe's Paris rose to #12 amid rising unicorns, signaling robust investor response to these life-improving innovations.[6] Trellis Group's Climate Tech 25, drawn from 109 applicants across